Category Archives: Clinical research

Statistical Design: Clinical Development of Drugs and Biologics

A few years ago, my colleague Steven E. Linberg was teaching a course, “Clinical Development of Drugs and Biologics,” at Johns Hopkins University. He asked me to give a guest lecture on statistical design. The class was once per week, … Continue reading

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Using ASIA Motor Score as outcome in spinal injury

In October ’06, the people at ICORD (International Collaboration On Repair Discoveries) in Vancouver asked me to give a talk. I spoke on Statistical Considerations in Designing a Trial in Spinal Cord Injury with ASIA Motor Score as the Outcome, … Continue reading

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Reduced Bladder and Bowel Control after Severe Spinal Cord Injury — Even in Patients Able to Walk

Regaining unlimited mobility, including the ability to walk, is a main goal for spinal-cord-injured (SCI) patients. Still, more limited accomplishments — such as bladder and bowel control — would significantly improve quality of life for those lacking them. Conferences and … Continue reading

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More on clinical trial design for beginners

My earlier post Clinical trial design — for beginners has been one of my more popular ones. People who’ve read that and would like to know more, can download

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Medicine: Using probabilty to treat people versus using it to treat groups

I saw an interesting post complaining about the “magic” of clinical trials and the refusal by many people to consider other types of evidence rationally. One commenter there replies, “Let me give you an example I like to use. George … Continue reading

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Clinical trial design — for beginners

This post is based on an e–mail series I sent to a friend in industry. He was responsible for overseeing the design of a clinical trial, and he asked me as a professional to tell him in simple words how … Continue reading

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